Eugene, OR—A gymnemic acids (GA) lozenge has been shown to reduce the brain’s reward response to both the taste of and the anticipated taste of a high-sugar milkshake, according to a press release from the Oregon Research Institute (ORI).
The study was performed on 40 healthy men and women with a fondness for sweet food. It was a double-blind crossover study. Participants ate 52% less candy on the day they received the gymnemic acids (GA) lozenge than the day the received the placebo lozenge.
Gymnemic acids come from the Gymnema sylvestre plant, which has been used in Ayurvedic medicine to treat a variety of ailments.
Eric Stice, Ph.D., and his team at the ORI conducted the study, titled “Effects of gymnemic acids lozenge on reward region response to receipt and anticipated receipt of high-sugar food,” published in Physiology & Behavior. While the plant has long been known to reduce taste of sugar, this particular study used functional magnetic resonance imaging to show that GAs block sweet taste receptors.
The research also showed that an initial taste of a high-sugar food increases reward region response to anticipated intake of more of the high-sugar food, and that GAs significantly reduces activation in the brain in response to anticipated tastes of high-sugar food as well as response to the actual taste of the high-sugar food.
“The evidence that blocking sweet taste receptors with gymnemic acids reduces anticipated reward from high-sugar beverages is a very novel finding,” Stice said in the release. “This may be a game-changer regarding approaches for reducing intake of high-sugar foods.”