Supporting Cognitive Function with Magtein *Sponsored Content*

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The brain is a complex organ. In one person’s lifetime, the brain processes billions of pieces of input from the outside world, and coordinates many of the body’s functions. As the brain ages, and as is the case with all “muscles,” the brain loses efficiency, resulting in declining cognitive function. Symptoms include trouble with memory and recall, decreased attention, poor sleep quality and increased anxiety. The brain naturally goes through a number of structural and functional changes as we age. Brain growth peaks around our mid-20’s, and then our brain volume begins to shrink at a relatively slow and steady rate.[1] Research has found that this shrinkage equates to roughly 5% per decade once we reach 40 years of age, and accelerates to an even greater degree after age 70.[2] While these changes are inevitable to some degree, our genetics, diet, lifestyle and environment also play a big role.[3] And, this means that we have the ability to support brain function through lifestyle choices, such as exercising the brain with special cognitive exercises, reading, learning and engaging with other people. We can also support brain function with good nutrition including high quality nutritional supplements.

How does a “shrinking” brain manifest itself?

The major factors behind a shrinking brain include loss of neurons (brain cells) as well as reductions in dendritic branching, synaptic density and myelin fibers.[4] So, what does this mean and why does it matter? Simply put, our brain cells rely on dendrites to be able to send and receive signals to one another. These signals are transmitted through synapses. Think of it as electrical signals being sent through wires. Myelin fibers act as an insulator for these electrical signals, allowing them to fire more rapidly. Our brain cells form new dendrites through dendritic branching, in turn, forming new synapses and increasing synaptic density. This is key because the more populated and dense these connections, the stronger, faster and more efficient our brain cells can communicate and vice versa.[5],[6]

Given these changes in our brain structure over time, it’s no wonder we experience the many common symptoms of “getting older.” Although some of this is certainly normal, chronic mental health issues are also becoming more widespread. An estimated 70 million adults in the United States have some form of sleep disorder, most commonly insomnia.[7] More than 18% of the population suffers from an anxiety disorder and nearly 10% suffers from a mood disorder.[8],[9] For some, these conditions may be just the beginning and might perhaps be a warning sign for their cognitive health down the road. For instance, studies have shown that people who report issues with memory or depression earlier in life are at greater risk for developing mild cognitive impairment, or even dementia, later on.[10],[11],[12]

We can help support our brain function

The good news: there are plenty of steps we can take to keep our aging brains healthy. Along the way, we can even lower our stress levels, improve our sleep and even remember why on earth we got up and walked into this room. We are well aware that a healthy diet and lifestyle are key to brain health, just as they are to overall health. Beyond that, increasing attention is being turned to natural and condition-specific solutions, particularly in the supplement and functional food space.

The brain health category is no longer being viewed as only important to the aging population. Rather, younger and middle-aged adults are becoming increasingly interested in products to enhance mood, memory and attention.  According to a Research and Markets report, the currently $2.3 billion brain health supplements market is expected to rise at a 19.6% CAGR over the next eight years, reaching an estimated $11.6 billion by 2024.[13] While some of this growth is being driven by traditional medicines such as ginkgo, ginseng and adaptogenic herbs, manufacturers are also developing more inventive solutions, with unique mechanisms of action, to meet consumer needs. Additionally, consumers are asking for solutions that are science-proven, to help ensure efficacy and quality.

AIDP’s Magtein® Provides Science-Proven Solutions to Support Cognitive Function and Sleep

Magtein, an AIDP innovation with the help of MIT scientists, is a patented compound of magnesium that offers a distinct approach to brain health by restoring old neurons, increasing synaptic density and ultimately decreasing the brain’s age. Magnesium is an essential cofactor for over 300 systems that regulate biochemical reactions in the body, including brain and nervous system function.[14] However, in order to be effective for brain health, it has to be able to actually reach the brain. Most magnesium compounds on the market have low ability to cross the blood-brain barrier, due to their chemical structure. Magtein is the only magnesium compound that has been shown to effectively raise the brain’s magnesium levels.[15] Furthermore, in-vivo research has demonstrated significant increases in brain synaptic density with Magtein supplementation, which then returned to original levels within two weeks of stopping supplementation.15,[16] These findings offer an explanation of Magtein’s unique mechanism of action.

Clinical research has demonstrated Magtein’s effectiveness in improving markers of cognitive health and function, including working memory, short- and long-term memory, attention and stress. In a randomized, double-blind, placebo controlled trial, Magtein® supplementation for 12 weeks resulted in significant improvements in memory and cognition in middle-aged and older adults.[17] A striking finding of this trial was a 10% improvement in Trail Making Test- Part B (TMT-B), which is a clinical assessment of executive function that evaluates visual attention, motor speed and impulsivity. Furthermore, a composite score of several cognitive assessments revealed a statistically significant improvement in cognitive ability, equivalent to a nine-year reduction in “brain age” among participants. Improvements in sleep quality, stress and anxiety are also commonly reported with Magtein supplementation.

Look for quality ingredients that are science-proven

AIDP’s focus is on high quality functional ingredients that are supported by science. In today’s complicated regulatory landscape, it’s important that consumers are guaranteed that they are buying supplements that have gone through all the rigorous testing needed. As baby boomers age, and more people are experiencing some level of cognitive dysfunction, the need for alternatives to prescription drugs is increasing. Magtein is sourced from magnesium, and the patented formulation, magnesium l-threonate, has been shown to not only slow down, but also reverse the effects of aging on the brain.

References

[1] Liu K, Yao S, Chen K, et al. Structural Brain Network Changes across the Adult Lifespan. Front Aging Neurosci. 2017;9:275.

[2] Peters R. Ageing and the brain. Postgrad Med J. 2006 Feb;82(964):84-88.

[3] National Institute on Aging. Risks to Cognitive Health. https://www.nia.nih.gov/health/risks-cognitive-health. Updated May 17, 2017.

[4] Gautam P, Cherbuin N, Sachdev PS, Wen W, Anstey KJ. Relationships between cognitive function and frontal grey matter volumes and thickness in middle aged and early old-aged adults: The PATH Through Life Study. NeuroImage. 2011 Apr 1;55(3):845-855.

[5] Tavosanis G. Dendritic structural plasticity. Devel Neurobio. 2012 Jan;72(1):73-86.

[6] Morrison JH, Baxter MG. The Aging Cortical Synapse: Hallmarks and Implications for Cognitive Decline. Nat Rev Neurosci. 2012 Mar 7;13(4):240-250.

[7] Centers for Disease Control and Prevention. Unhealthy Sleep-Related Behaviors – 12 States, 2009. MMWR 2011 Mar;60(8):233-268.

[8] National Institute of Mental Health. Any Anxiety Disorder Among Adults. https://www.nimh.nih.gov/health/statistics/prevalence/any-anxiety-disorder-among-adults.shtml.

[9] National Institute of Mental Health. Any Mood Disorder Among Adults. https://www.nimh.nih.gov/health/statistics/prevalence/any-mood-disorder-among-adults.shtml.

[10] Jessen F, Wiese B, Bachmann C, et al. Prediction of Dementia by Subjective Memory Impairment: Effects of Severity and Temporal Association with Cognitive Impairment. Arch Gen Psychiatry. 2010;67(4):414-422.

[11] Jonker C, Geerlings MI, Schmand B. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriat Psychiatry. 2000 Nov 23;15(11):983-991.

[12] Chen ST, Siddarth P, Ercoli LM, et al. Modifiable Risk Factors for Alzheimer Disease and Subjective Memory Impairment across Age Groups. PLOS ONE. 2014 June 4;9(6): e98630.

[13] BusinessWire. Global Brain Health Supplements Market 2016 to 2024: Focus on Memory Enhancement, Mood and Depression, Attention and Focus, Longevity and Anti-aging, Sleep, Recovery and Dream Enhancement and Anxiety – Research and Markets. http://www.businesswire.com/news/home/20170621005628/en/Global-Brain-Health-Supplements-Market-2016-2024-Focus. Published June 21, 2017.

[14] Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 May 1;4(3):378S-383S.

[15] Sun Q, Weinger JG, Mao F, Liu G. Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration. Neuropharmacology. 2016;108:426-439.

[16] Slutsky I, Abumaria N, Wu L, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010 Jan 28;65(2):165-177.

[17] Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimer’s Dis. 2016;49:971-990.

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