Ashwagandha
Ashwagandha has been clinically proven to be good for the body. KSM-66 Ashwagandha is a clinically studied Ashwagandha root extract, backed by gold-standard clinical trials and studies on healthy populations, and offers a wide range of benefits. Also offering ashwagandha: “A new study shows our Prolanza long-acting ashwagandha can significantly reduce stress 9.3-fold in just a 300 mg daily dose,” says Jennifer Clancy, Global Marketing Director, Nutriventia. “An in vivo study showed it may combat stress-related inflammation by reducing TNF-α and IL-1β and minimizing oxidative stress through reduced superoxide production. With its 12-fold better bioavailability compared to a leading ashwagandha, Prolanza offers an effective solution for stress management.”
Beets
Sabinsa offers Sabeet Beta vulgaris L., a water soluble extract of Beta vulgaris L. standardized to have a minimum of 2% nitrates. “Sabeet consumption was found well tolerated and safe in geriatric population, " says Shaheen Majeed, Global CEO & Managing Director, Sabinsa Corporation. “Sabeet lowers blood pressure and improves blood lipid and glucose levels. It is known for its antioxidant and antitumor activities. It is available in many dosage forms including tablets, capsules, food formulations, and beverages.”
Berberine
Indena offers Berbevis Berberine Indena Phytosome for a healthy metabolism with an optimized bioabsorption profile. Cosimo Palumbo, Chief Commercial Officer, Indena USA Inc., explains that the Indena Phytosome delivery system is a multi-talented technology platform that unlocks the power of phytonutrients, also optimizing the bioabsorption and pharmacokinetic profile of many natural ingredients. “Scientific evidence has shown that Berbevis is effective in maintaining a balanced blood sugar and lipid metabolic profile and managing healthy body parameters.”
Bergamot
“Bergacyn is a unique blend of bergamot polyphenolic fraction (BPF) from Citrus bergamia Risso (bergamot) and Cynara cardunculus,” Annie Eng, CEO, HP Ingredients. “This new ingredient is targeted at the liver-support category with several clinical trials completed to support its label claims. Bergacyn has two human double-blind, placebo-controlled, randomized clinical studies: a12-week trial of 80 participants with metabolic disorders who consumed 600 mg daily, and resulting in statistically significant reductions in steatosis (fat buildup), and a 16-week comparison study of 80 participants with type 2 diabetes mellitus who consumed either 300 mg Bergacyn, 300 mg bergamot extract or 300 mg C. cardunculus extract, or placebo. This study showed that Bergacyn supplementation had a far greater effect on reducing inflammatory markers and produced significant improvement of NAFLD biomarkers.”
Biotics blends
Innovating with -biotic blends, Palumbo shares, “Through a strategic partnership with dsm-firmenich, Indena has introduced several jointly developed product formulations combining top quality active botanical extracts with biotics and essential nutrients targeting a wide range of health platforms while elevating the consumer experience through delicious, easy-to-use formats such as gummies and oral dispersible granules.”
From IFF comes premium probiotics, botanicals and health ingredients backed by science, that support digestion, bladder wellness, metabolic health, cognitive performance, menopause and more, all aimed at enhancing consumers’ quality of life. “Metabolic health is a key focus, and our formulations leverage ingredients that support healthy weight management,” says Mindy Wetzel, Na Regional Marketing Leader – IFF Health. “One product concept includes Litesse Ultra, which stimulates the natural production of GLP-1 to regulate appetite, and HOWARU Shape (B420), which aids digestive health. We also have several menopause concepts leveraging IFF’s expertise in formulating ingredient combinations for optimal benefits and stability. Each concept targets specific menopause symptoms and needs, from night sweats to weight management. The Mystic is an all-in-one formula powered by probiotics and plant extracts to effectively address hot flashes, feelings of stress, and support sleep quality. The Warrior is a “triple threat” featuring probiotics, plant extracts, and essential vitamins that support metabolic health and natural weight management. Meanwhile, the Healer is a powerful combination of a probiotic clinically shown to support skin health, and key vitamins that nurture beauty from within. All of our concepts use clinically backed ingredients and are available in an array of customizable and finished product formats to expedite market access.”
Black Seed Oil
“ThymoQuin is currently the only black seed oil to meet the USP monograph, with six awarded global patents, and six approved Health Canada structure function claims,” says Morris Zelkah, CEO, TriNutra. “Dr. Michael Murray is TriNutra’s latest brand partnership to launch a finished product with this award-winning ingredient. ThymoQuin has shown support for metabolic health, fatty liver support, immune health (1,2,3,4), and cardiovascular health. ThymoQuin is ideal for dietary supplements.” And ThymoQuin-OCare is a black seed oil for improved halitosis (bad breath) and sensitive teeth. It is standardized to 3% thymoquinone with at least 1.2% p-Cymene (the main bio-actives in black seed with synergistic action) and less than 1.25% free fatty acids.
The company also offers B’utyQuin, a beauty application of black seed oil that supports a healthy inflammatory response and promotes a healthy microbial balance. “B’utyQuin has been clinically shown to aid in skin hydration, luminosity, firmness and elasticity as well as scalp soothing and relief of redness, scaling and itch,” Zelkah says. “B’utyQuin has a wide range of applications from skin care to hair care to intimate care.”
Capsanthin
“CapsiClear, an award-winning eye-health ingredient, is the first-ever capsanthin extract from Capsicum annuum clinically shown in a published study to alleviate dry eye symptoms, promote tear regeneration, and decrease corneal inflammation,” reports Sevanti Mehta, President, Unibar Corporation. “This nature-derived carotenoid has also been clinically studied to reduce eye fatigue, improve macular pigment ocular density, support healthy intraocular pressure, and provide blue light protection. CapsiClear is the only 5-in-1 eye health ingredient with benefits for daily and long-term vision support.” The company also offers Bellaneo, a clinically studied, patent-pending capsanthin extract that has been shown to support skin elasticity, provide antioxidant protection, and hydrate the skin. It can be incorporated into cosmetic oils, creams, and topical treatments.
Citicoline
“We’re excited to share an innovative discovery about Cognizin citicoline and its impact on brain health—at a DNA level,” says Maria Stanieich, Senior Marketing Manager Kyowa Hakko U.S.A., Inc. “This groundbreaking new science highlights the mechanism of citicoline at the genetic level and substantiates the benefits we see in healthy subjects. Recent studies have unveiled the intricate mechanisms behind citicoline's neuroprotective effects. Using an integrative high-resolution transcriptomic approach in human cell systems, researchers have shed light on how this powerful compound provides insights into future research in advancing healthy brain aging. This latest data reinforces that Cognizin is a safe and efficacious ingredient, supporting comprehensive brain health at a DNA level. You can feel even more confident knowing you’re providing the best ingredient for this top-demand consumer need. Cognizin provides brain performance as well as more comprehensive brain health support over time. This brain health nutrient has demonstrated through multiple clinical trials that it provides essential benefits to people of all ages.”
Citrus flavonoids
“Eriomin is an award-winning, high potency lemon flavonoid extract,” says Rob Brewster, President, Ingredients by Nature. “It is backed by three human clinical trials demonstrating its ability to support healthy glucose levels, boost GLP-1, provide strong antioxidant support and a healthy inflammatory response.SynChoice is a bitter orange extract for healthy weight management. Ingredients by Nature is now offering this ingredient to the industry for dietary supplements, food and beverage applications. Sytrinol is a proprietary ingredient that combines citrus-derived polymethoxylated flavones (PMFs) with tocotrienols and has been clinically shown to deliver powerful heart health benefits. It was shown to significantly modulate three markers of cardiovascular health in as little as four weeks. The study subjects had reduced cholesterol levels by 27%, LDL by 25%, and triglycerides by 31% compared to the placebo. In addition, Sytrinol has two patents for its heart health benefits, is vegan, kosher, and self-affirmed GRAS. The product is also versatile and can be incorporated into various delivery formats to meet the consumer needs of modern finished products.”
Collagen
“With over 130 years of collagen expertise, Rousselot is dedicated to unlocking the hidden messages and targeted health benefits contained within collagen peptides,” says Gaëtan Noiret, Global Director, Health & Nutrition at Rousselot. “The company’s latest innovation, Nextida, is a groundbreaking platform of specific collagen peptide compositions with new targeted health benefits, aiming to guide the body back to balance, naturally. For the first practical application of the Nextida platform, Rousselot’s researchers focused on the growing concern of blood glucose control, exploring whether a carefully selected collagen peptide composition could support the wellbeing of supplement consumers. The result of this breakthrough approach is Nextida GC, designed to help healthy people maintain balanced glucose levels after a meal. Promising pre-clinical studies have demonstrated the ingredient’s impact on the incretin effect, the body’s mechanism for regulating glucose spikes, in which the hormone GLP-1 (glucagon-like peptide 1) plays a major role. Given collagen’s widespread recognition among consumers as a trusted natural and safe ingredient with multiple health benefits, Nextida GC offers an exciting opportunity for nutraceutical and dietary supplement brands to meet the growing demand for natural wellness products.”
Cucumber extract
“Euromed’s new cucumber extract CuberUp is a potential natural approach to the maintenance of healthy joints,” says Andrea Zangara, Head of Scientific Marketing & Medical Affairs, Euromed. “Backed by a double-blind clinical study, the extract has a positive impact on knee pain, mobility and muscle function in people over 40 years with knee function limitations.”
Curcumin
“Meriva Curcumin Indena Phytosome, known as The Life Guardian, is among the most studied curcumin ingredients on the market, with a proven unique bioabsorption profile of all three natural curcuminoids and over 40 clinical studies involving more than 2,000 subjects,” says Palumbo. “Its efficacy has been demonstrated in a wide range of health areas, including cardiovascular, intestinal and ocular health, sports nutrition, joint health, healthy blood levels, and most recently, kidney health. Meriva is supported by strong clinical evidence for joint health and has also been shown to help maintain healthy bone density.”
DHA and EPA
“GC Rieber VivoMega now offers EPA+DHA Algae 2050 TGP oils,” says Ståle Søfting, Sales and Marketing Director, GC Rieber VivoMega. “This high-concentration, non-GMO, vegan omega-3 from microalgae offers superior quality and purity with environmental and sustainable initiatives at the forefront. VivoMega’s algae concentrate is 90% triglycerides, which offers increased bioavailability for improved absorption in the body. It also comprises 73% long-chained omega-3 fatty acids and is Vegan certified.”
The company also recently completed its $75 million facility expansion to meet the growing and varying consumer needs. “This expansion is a significant capacity increase for VivoMega ingredients from fish and algae,” Søfting says. The company added:
A 38,000 metric ton storage tank park
An electric steam boiler which allows its three facilities to run on 100% renewable energy
Additional heating capabilities to help maintain the quality of the oils and allow for easier extraction in winter
Additional nitrogen to remove oxygen for improved sensory profiles
Elderberry
“New clinical science highlights specific gut benefits of elderberry’s polyphenols, secondary plant metabolites that reach the colon intact, helping to re-establish the mucosal epithelial barrier, restrict the growth of opportunistic pathogens, and free up niches for beneficial bacterial strains,” says Leslie Gallo, President, Artemis International. “A human clinical study with our ElderCraft European black elderberry extract shows that supplementation with polyphenol-rich elderberry extract increases the abundance of the beneficial bacteria Akkermansia, Bifidobacteria and Lactobacilli. Our ElderCraft Black Elderberry Extract sets the standard for premium polyphenol-rich solutions.”
Fenugreek seeds
“In 2024, Artemis began a substantial portfolio expansion with Fenuflakes, a formulation of debittered, defatted flakes of fenugreek seeds that is fiber- and protein-rich yet low in fat and carbohydrates,” says Gallo. “Fenuflakes is formulated to support healthy blood sugar levels, lower the glycemic index of high-glycemic index foods, and improve gut health. Products with a low glycemic index, reduced carbohydrate count, and overall less sugar are especially beneficial for people with diabetes, a cohort of 11.6% of the U.S. population, including those undiagnosed.”
French maritime pine bark
“Pycnogenol is a natural extract from French maritime pine bark,” says Sébastien Bornet, VP Global Sales & Marketing, Horphag Research (exclusive worldwide supplier of Pycnogenol). “This premium ingredient is known for its unique blend of procyanidins, bioflavonoids, and phenolic acids which offers extensive health benefits, from improved cardiovascular health, cognitive function to enhanced skin care. Adding to its 40 years of research and more than 160 clinical studies, a recent study found that Pycnogenol can improve healing and reduce skin discoloration following sclerotherapy, a minimally invasive procedure used to manage spider veins. The study involved 161 women treated with standard compression sclerotherapy for spider veins; 84 participants took 150mg of Pycnogenol daily starting the day before sclerotherapy and continued for 12 weeks, alongside standard management. The participants who took Pycnogenol showed a significant reduction in skin discoloration post-sclerotherapy, with a lower average skin staining score and fewer discolorations per treated vein compared to the control group. This study not only highlights the importance of addressing skin discoloration after sclerotherapy for overall skin health, appearance and confidence, but it also underscores the potential for skincare formulations to leverage Pycnogenol’s vast benefits. Recognized for its powerful antioxidant and anti-inflammatory properties, Pycnogenol is available in both oral and topical forms and is featured in over 1,000 health products worldwide.”
Ginger
“Ginfort is the world’s first powdered ginger extract containing >26% gingeroids (gingerols and shogaols),” says Zak Benmerzouga, Business Director, AIDP. “Patented and highly soluble, Ginfort delivers more than 12x the gingeroid and 6-gingerol content of traditional ginger rhizome. Ginfort is clinically studied to reduce discomfort from primary dysmenorrhea at 200mg per day, and relieves symptoms of functional dyspepsia, improving postprandial fullness, abdominal bloating, and early satiety at 400mg per day.”
Glutathione
“Setria is the brand name for glutathione,” says Stanieich, noting that Kyowa Hakko has been making it since the 1960s. “Glutathione itself is considered a master antioxidant and one of the most important antioxidants our body makes. Every single cell, even down to single-celled organisms, makes glutathione. That's how important it is in this world to scavenge and help with reactive oxygen species. Glutathione itself is considered a master antioxidant because it can neutralize many different types of reactive oxygen species or oxidants that are out there. It can also recycle other antioxidants that are important in our bodies like vitamin C and vitamin E. It has many roles in terms of being a versatile antioxidant, and it is one of the most important antioxidants out there. A 2015 clinical study demonstrated supplementing with Setria can increase both blood levels and body compartment stores of glutathione when taken daily. The researchers concluded that these findings indicate that daily consumption in supplement form is effective at increasing body compartment stores of glutathione. This clinical trial suggests that the ultimate goal of supplementation with glutathione should be to enhance the body’s levels of this critical antioxidant.”
Immunoglobulins
“We continue to add to our library of data supporting its efficacy, with a new study that looks into the function of Immunolin,” says Andy Hewitt, Marketing Manager, Proliant Health & Biologicals. “We already know that it binds to antigens and keeps them from crossing the gut barrier and causing an inflammatory response, but this study looks at how Immunolin is modulating the microbiome. The study provides us with enough data to support another mechanism of action in that Immunolin has prebiotic effects and supports the healing of the gut, helping reduce inflammatory antigens. It also uncovered new information that Immunolin can help increase short chain fatty acid production and the bacteria that produce them, along with increasing the production of health-promoting tryptophan metabolites. Earlier in 2024 we also looked at the interaction of Immunolin with aflatoxins. According to the U.S. Centers for Disease Control and Prevention, approximately half of the world’s population are chronically exposed to aflatoxins through their regular food consumption. In our study, we were able to demonstrate that the immunoglobulins in Immunolin have the potential to help manage the effects of aflatoxin exposure by binding to the structures themselves.
Lemon Balm
“Relissa Melissa Indena Phytosome is lemon balm (Melissa officinalis) formulated with Indena Phytosome to optimize the performance of its acknowledged phytonutrients/phytoactives, such as hydroxycinnamic and rosmarinic acids, for better, more effective results,” says Palumbo. “Relissa has demonstrated beneficial effects on mental and sleep health in adults in balancing moods, improving sleep latency, and countering stress.”
Gallo adds that another key element of Artemis’ expansion beyond science-supported berry extracts and powders is its new line of phyto-nutrient ingredients, including a select group of especially beneficial botanicals including lemon balm, as well as black cohosh,psyllium husk, and top-requested mushroom powders including lion’s mane, cordyceps, reishi, and shiitake.
Lion’s Mane
“Earlier this year, Sempera Organics launched SO-DSX1, the world’s first clinically validated lions’ mane blend for cognition improvement and stress reduction in healthy adults,” says Nirmal Nair, Founder/CEO, Sempera Organics. “The study was published in the December 2023 issue of Nutrients magazine. This double-blind, placebo-controlled study of a lion’s mane ingredient in a healthy population revealed an additional benefit – reduction of perceived stress. In the study, adults aged 18 to 45 consumed either 1.8 g SO-DSX1 or placebo daily for 28 days. They were tested at one-hour (acute) and 28-days (chronic) post consumption. Results showed improvements in Stroop task time after one hour and Visual Analog Score (VAS) after 28 days. These results demonstrate that SO-DSX1 is appealing for adults who seek a mental competitive advantage in their professional lives (and at home) combined with a heightened sense of well-being through stress reduction. Consumers can feel the difference in just under a month. Mushrooms are booming in beverage product development, with such iconic companies as PepsiCo adding lion’s mane to its line of Rockstar Energy. Consumers are increasingly adopting adaptogens and ingredients that promote higher senses of wellbeing as part of their daily rituals. Sempera Organics is working diligently in this space to improve mushroom inclusion in beverages.”
Lutein
“UniGold is Unibar’s patented, GRAS-affirmed standardized trans-lutein extract,” Mehta shares. “This bioavailable form of lutein can provide health benefits similar to those of the lutein used in the AREDS2 study. Unibar also offers free lutein, lutein esters, zeaxanthin, and meso-zeaxanthin. In addition, Unibar’s portfolio of lutein and zeaxanthin ingredients is backed by Farm to Finish sustainability. From cultivating marigold flowers using precise irrigation techniques to leveraging renewable energy, Unibar is committed to improving the health of the people and the planet.
Magnesium
“ATA Mg (magnesium acetyl taurinate) is a patented magnesium and taurine with enhanced cellular and brain bioavailability,” says Benmerzouga. “ATA Mg, having a lipophilic structure, has been shown to have a higher cellular bioavailability and absorption than other traditional magnesium salts. ATA Mg has clinical evidence for PMS support at 770 mg per day. It is also water-soluble, making it an ideal ingredient for many delivery systems.”
Mediterranean ingredients
“Bionap produces sustainable Mediterranean ingredients grown in the areas surrounding Mt. Etna UNESCO World Heritage Site,” says Tyler Ris, Vice President of Sales, North America, Bionap USA Inc. “These volcanic-enriched soils have a unique mineral and chemical profile that impart distinct attributes in the ingredients Bionap offers. From the initial selection of raw materials to the final extracts, Bionap strictly controls the whole production process to ensure the highest manufacturing standards. The safety and effectiveness of Bionap ingredients are supported by continuous scientific research and clinical trials that have been published in international scientific journals. Bionap ingredients include: Recently introduced ODILIA Prickly Pear Prebiotic is an upcycled, low-dose prebiotic produced with zero waste that supports a healthy gut microbial populations and supporting overall wellness. MOROSIL is Sicilian Blood Orange obtained from a unique cultivar of the Moro red orange with supporting clinical studies for weight management. “Studies with MOROSIL have demonstrated significant reduction of body weight, BMI, and waist and hip circumference,” Ris says. The company also offers ACTRISAVE for natural protection against hair loss and acne. It combines anthocyanins contained in black rice and cactus flower flavonoids for a synergistic protective effect on skin and hair. Ris adds, “Bionap’s vision for the future is to spread the principles of the Mediterranean tradition to improve people’s health and well-being.”
NAD
Demand for effective Nicotinamide Adenine Dinucleotide (NAD+) products is surging, according to the team at BLS. “NAD+ fascinates researchers because it drives cellular energy and DNA repair, among many important metabolic functions,” says Marianne McDonagh, BLS Vice President of Sales. “A decline in NAD+ levels, whether due to age, stress, lifestyle, poor diet or other factors, may accelerate the overall aging process…More consumers now understand that when your NAD+ level is low, you may experience brain fog, loss of stamina, low energy and/or poor sleep quality. They are looking for safe and effective ways to support healthy aging by optimizing their NAD+ levels. BLS is giving the industry multiple ways to satisfy that need.” BLS offers RiaGev, suitable for supplements, foods and beverages, as well as topically in cosmetics and personal care products. It is available in multiple formats including sustained release (RiaGev-SR) which is designed to mimic food digestion to provide superior benefits to the consumer, and water soluble (RiaGev-WS) which can be used in food and beverages.
Nootropics
“As interest in nootropics continues to grow, TSI Group proudly offers a powerful combination of ingredients that enhances both physical and cognitive performance,” says Shawn Baier, MS, MBA, Vice President of Business Development, TSI Group. “By pairing enfinity (paraxanthine) with PEAK ATP, this combination delivers a potent boost in energy, reduces fatigue, and sharpens focus. enfinity, a revolutionary caffeine alternative, has quickly gained recognition for providing the stimulating effects of caffeine with fewer side effects. Unlike caffeine, enfinity is metabolized more efficiently, resulting in improved focus, a lower heart rate, and increased energy expenditure. Studies have even shown that enfinity surpasses caffeine in enhancing cognitive function, especially after demanding physical activity.PEAK ATP, a cornerstone of sports nutrition, is celebrated for its ability to increase blood flow, enhance muscle activation, and support cognitive function following intense exercise. It distinguishes itself among stimulant-free energy supplements by offering benefits that go far beyond simply boosting energy.”
Baier adds that PEAK ATP provides immediate cellular energy, while enfinity enhances focus and combats fatigue by modulating adenosine receptors. “Together, they offer sustained energy, improved cognitive clarity, and enhanced muscular endurance, making them the ideal choice for those seeking to push their limits. enfinity not only increases focus and mental performance but also supports fat oxidation. Simultaneously, PEAK ATP proves its value by reducing fatigue, boosting strength, and enhancing recovery, securing its role in advanced supplement formulations.”
PEA
“Levagen+ is our branded palmitoylethanolamide (PEA) with LipiSperse, a revolutionary ingredient with 13 published clinical studies and more on the way,” says Maggie McNamara, Vice President of Global Marketing, Gencor. “Levagen+ is absorbed within 45 minutes, with x1.75 absorption compared to standard PEA. PEA is an endogenous fatty acid amide produced naturally in the body in response to injury and stress. It has essential anti-inflammatory, analgesic, and neuroprotective properties and is categorized as part of the extended endocannabinoid family with similar health benefits. Clinically, research benefits include joint health, sleep health, recovery, immunity, skin health, inflammation, and discomfort relief. A new, soon-to-be-published study with Levagen+ also shows great promise for women’s health.”
Postbiotics
“IMMUSE is a novel postbiotic,” says Stanieich. “This patented unique strain of Lactococcus lactis activates the pDCs (plasmacytoid dendritic cells), the commander and chief of the immune system. Through a process that took us decades of scientific innovation to bring to market and has now been used successfully in Japan for a decade, where it won the nation’s top innovation award. This mechanism has never been seen before! The pDCs activate or direct other immune cells to take action. pDC, a key leader of the immune system, organizes other immune cells, such as NK, Killer T, Helper T, and B cells for a more comprehensive approach to immune support. Common lactic acid bacteria improve the intestinal environment by being delivered live and functioning in the large intestine, thereby indirectly enhancing the immune system. IMMUSE, in contrast, has been found to directly activate the pDC, which is mainly located in the small intestine. The activated immune cells circulate throughout the body, thus supporting immune health from the inside, in addition to functioning in the intestines. IMMUSE has a novel mechanism of action to activate pDCs. This mechanism of action differentiates IMMUSE from more conventional lactic acid bacteria or other immune ingredients as they are not able to activate the pDCs. Backed by multiple safety and immune health studies, IMMUSE has shown several benefits to support year-round health.”
Prebiotics
“AlphaGOS is a plant-based Galactooligosaccharide (GOS) prebiotic derived from peas, which boosts Bifidobacterium and modulates short chain fatty acid production,” says Benmerzouga. “It has over 23 studies. The human clinical trials support modulation of gut microbiota, improved metabolism in overweight individuals and decreased inflammation. Invitro culture of infant microbiota demonstrates a bifidogenic effect superior to other oligosaccharides used in infant formulas.”
Probiotics
Sabinsa offers LactoSpore Heyndrickxia coagulans (Bacillus coagulans) MTCC 5856. “This heat- and storage-stable probiotic was found to be safe and effective in managing acute diarrhea in children in a recent clinical study,” says Majeed. “LactoSpore maintains microbial homeostasis, resists the growth of pathogens, and produces organic acid (lactic acid) and short-chain fatty acids (SCFAs). It also possesses immune modulatory effects and helps to maintain overall intestinal morphology and function.” It is available in powder form with 6/15/100 billion bacteria/gram. LactoSpore is stable in apple juice, glucose syrup, waffles and muffins, and breweries, he adds. It can be formulated as gummies, beverages, tablets, capsules, and ready-to-mix powders.
Alexis Collins, Director of Product & Brand Strategy, Stratum Nutrition says Stratum Nutrition recently became the sole North American distributor of oraCMU, an oral probiotic that helps promote fresh breath by reducing the production of malodorous gasses created by oral bacteria and by supporting a healthy oral microbiome. “Even better, oraCMU has demonstrated this effect in both human and canine clinical trials, so cheers to reducing ‘dog breath’ all around! For humans, 100 million CFU can help maintain fresh breath and support overall oral health. For dogs, oraCMU is effective in doses ranging from 20 million to 2 billion CFU daily.”
Pomegranate extract
“In a recently published pre-clinical study, Euromed’s pomegranate extract Pomanox was shown to reduce the adverse effects of high fructose consumption, such as weight gain, hepatic steatosis, dyslipidemia, inflammatory and immunological responses,” reports Zangara. “Another recent study revealed that Pomanox reduced the age-related involuntary weight loss, providing a possible approach to an important aspect of frailty in the elderly, and highlighting its potential in overall weight management.”
Rhodiola
“LANDKIND Pure Salidroside is exemplary of our sustainability commitment and expertise in fermentation,” says Julie Lemahieu, Markets & Solutions Director, Gnosis by Lesaffre. “Rhodiola rosea, known for impacting energy levels, mood, and mental performance, takes over 20 years to mature. Increasing demand became the main threat of overharvesting. LANKIND Pure Salidroside is crafted by fermentation to protect the native Rhodiola botanical species. Our fermentation process creates the key bioactive Salidroside, bypassing the need to harvest Rhodiola rosea. A new study (pending publication) confirms LANDKIND Pure Salidroside’s benefits for sports nutrition.”
McNamara adds, “Gencor is thrilled to announce an exclusive distribution partnership with Gnosis, bringing U.S. companies the first and only fermented salidroside bioactive, LANDKIND Pure Salidroside. This partnership is a testament to our commitment to providing unique and effective solutions in sports nutrition.”
Sage
“Stratum Nutrition’s recently acquired sage extract is an ideal experiential ingredient that may help support memory and attention in as little as one hour and support healthy neurotransmitter levels,” says Collins. “It does not contain caffeine and offers nootropic support to those buying into the “non-stim” no-to-low caffeine wave. This sage extract is 100% traceable, non-GMO and standardized to specific bioactives to help support cognitive health. Stratum’s sage extract works efficiently, in many different delivery formats, with a very mild natural flavor. Best of all, the clinically substantiated dose range of 167mg-333mg makes including this ingredient for added cognitive support a ‘no brainer.’”
SAMe
“Adonat Premium SAMe (S-Adenosyl-Methionine) is the only registered SAMe brand in the market,” says Lemahieu. “An in-depth comparative quality-based evaluation of various SAMe ingredients confirms the premium quality profile. Methylation is a vital process in all cell life, which the body's systems need for proper functioning. The main methylating agent in our body is SAMe, which is endogenously produced and cannot be obtained through diet. From Young Adults to the Elderly, Adonat supplementation can support cognitive and mood health, joint and liver health, and contribute to longevity and health span.”
Shatavari
“Cepham is concentrating its research efforts towards sustainable aging selfcare for women and men,” says Anand Swaroop, Ph.D., Founder and President, Cepham. “Sustainable aging is a multi-dimensional concept that emphasizes the importance of facilitating a socially, economically, and environmentally sustainable aging process. Our research efforts are concentrated towards the lowest effective dose to ensure compliance and efficacy. The first of this product line we are offering is SheVari4 for women and AdoniXYen for men. While there is overall lack of research for women on the topic of aging health, men's health has primarily been focused on sexual health. We are trying to change the status quo by developing products addressing sustainable aging focused on a holistic approach.”
SherVari, which is derived from Asparagus racemosus roots (Shatavari), is undergoing a human clinical trial to assess its effects on hormonal balance, focus, mood, and immune support, Swaroop says. And the human clinical trial for AdoniXYen is focused on prostate health, sleep, and androgen deficiency. “Cepham product pipeline is focused on underserved areas of women's health such as anxiety, stress, ovarian and reproductive health. In men, the research is focused on mental, cardiovascular, occupational, and lifestyle health areas.”
Tongkat Ali
The botanical Eurycoma longifolia has been shown in a new study to support immune function when SARS-CoV-2 is present,” says Eng. Researchers utilized a mitochondrial metabolic activity assay to determine the cytotoxicity of the E. longifolia extract in Vero cells (mammalian cells used for viral research). The extract was tested for its antiviral activity at six different concentrations, ranging from 3.12 µg/mL to 50 µg/mL, and was found to inhibit SARS-CoV-2 replication in a dose-dependent manner.
“This study shows that a traditional herb has value for immune support, especially in times of stress,” says Eng, who adds that a recent study of the company’s LJ100 Tongkat Ali showed that it is effective at increasing testosterone while simultaneously reducing cortisol in a low 100 mg dose. This study, published in Andrology, supports two previous studies arriving at the same conclusion.”
Turmeric
“TurmXTRA60N, Nutriventia’s standardized, proprietary water-dispersible turmeric extract, recently was compared to a well-known turmeric-plus-piperine extract and found to be as effective in a lower dose,” says Jennifer Clancy, Global Marketing Director, Nutriventia. “TurmXtra is demonstrated to effectively deliver 150 mg curcuminoids at a single 250 mg dose.”
Vitamin C
“As winter approaches, immune support–and vitamin C–are in the spotlight,” says Clancy. “C-Fence sustained-release vitamin C is now available in direct compression (DC) granules. C-Fence DC granules ensure small doses of vitamin C are consistently released resulting in maintaining steady plasma concentrations for 24 hours.” She adds that Nutriventia has ramped up its delivery format portfolio–dispersible solutions (fast-dissolving tablets and orally disintegrating films), nano-encapsulation solutions including micellar systems, and confections such as gummies and functional chewing gums can be utilized to distinguish products from competitors.
Formulation Boosters
Aroma technology: “Lonza Capsules & Health Ingredients has launched AromatiQ™ technology—a new aroma capsule coating technology designed to help brands unlock a new frontier in supplement innovation by captivating consumers’ senses and enhancing their wellbeing experience,” says Juliana Erickson, Global Product Innovation Manager at Lonza Capsules & Health Ingredients.
“This pioneering capsule coating solution harnesses the power of naturally derived essential oils—such as peppermint and orange, and enticing aroma coatings to enable brands to create multi-sensory supplement moments for consumers. Lonza’s AromatiQ technology opens up a wealth of opportunities for brands to unlock new markets through sensory innovation, without compromising on efficacy, capsule delivery or performance.
“Lonza’s research shows that 70% of consumers would pay more for more enjoyable, memorable supplement experience. Its curated portfolio of capsule essential oil and aroma coatings can be used to match the intended health benefits of premium supplement formulations. For instance, citrus essential oils can match mood health supplements, while invigorating peppermint is associated with focus and vitality formulations. AromatiQ technology can also help mask strong-smelling ingredients like ashwagandha or valerian root.
Leveraging Lonza’s 120+ year legacy of capsule innovation and manufacturing, AromatiQ technology can be used with its Capsugel liquid-filled capsules portfolio in North America.”
Bioavailability boosters: Sebastian Balcombe, Medicinal Chemist, Founder & CEO, Specnova, says NovaQSpheres is Specnova’s newest ingredient delivery technology that offers a breakthrough in precision-controlled release of active ingredients into the body. “NovaQSpheres ensures a consistent and gradual release of active ingredients including vitamins, minerals, botanicals, and more, for prolonged therapeutic effects. This controlled-release profile significantly slows the absorption rate, allowing more of the active ingredient to reach the target tissues thoroughly and efficiently—without waste. In a recent study, NovaQSpheres Creatine Monohydrate Beadlets were tested in simulated intestinal fluid over a 10-hour period. A burst release of 52% of the creatine was observed within the first hour, providing an immediate surge. By hour eight a steady release of 95% of the creatine had been successfully delivered. This continuous release profile was found to create higher cellular creatine concentrations and raised the total ceiling of creatine levels within cells.”
Balcombe adds that NovaQSpheres goes one step further by incorporating LipoVantage Liposomes. “LipoVantage Liposomes are renowned for their ability to enhance bioavailability by increasing permeability, solubility, and stability within the body. NovaQSpheres is the only beadlet technology that offers liposomal ingredients in beadlet form, combining the superior bioavailability and performance benefits of liposomes with the precision-controlled release of a beadlet.”
Color & flavor enhancers: Lycored is a global leader in naturally derived carotenoids for food, beverage, and dietary supplement products, says Tammi Higgins, Senior Vice President, Commercial, Lycored. “By combining nature’s goodness with cutting-edge science, Lycored provides beautiful colors, taste components, and actives, helping customers create innovative food, beverage and nutraceutical brands to empower beautiful experiences from the inside out. The latest addition to Lycored’s robust lineup of nature-based colorants is ResilientRed BF, a naturally derived lycopene-based shade sourced from tomatoes. Ideal for UHT dairy, plant-based beverages, meat alternatives, and surimi seafood, ResilientRed BF offers resiliency and stability across pH, light, and heat extremes. This superstable, versatile colorant is the perfect companion for ‘free-from’ products intended to reach a high-end demographic, specifically meeting ingredient requirements for products sold at Whole Foods Market. ResilientRed BF is just one of Lycored's exciting new ingredient offerings, with more on the horizon. Constantly innovating to discover solutions that help brands deliver on consumer desires for good health, radiant skin, and active lifestyles, Lycored is announcing an expansion to the ‘beauty from within’ portfolio, set to launch at SupplySide West in October.” See page 26 for a deeper dive into colors and flavors.
