Company DescriptionHorphag Research (USA), Inc. is the exclusive North American supplier of Pycnogenol® French maritime pine bark extract and newly launched Robuvit® French oak wood extract. Based in Hoboken, NJ, Horphag Research (USA) has the exclusive rights to market and sell Pycnogenol® and Robuvit® and works with hundreds of companies to help them developinnovative and effective product formulations. The company mission remains deeply rooted in a commitment to scientific research surrounding high-quality nutritional ingredients and this is reflected in the quality of products offered to customers.

Over the past 40 years, Horphag Research has invested millions of dollars into scientific research. Today, Pycnogenol® is one of the most evidence-based health ingredients in the industry with more than 130 clinical trials on more than 10,000 patients, confirming its safety, non-toxicity and clinical efficacy. Horphag Research has also been awarded the Frost & Sullivan Excellence in Research Award, Nutraceutical Business & Technology Safety & Quality Award, SupplySide West Scientific Excellence Award and The American Botanical Council’s Tyler Research Award for its flagship ingredient, Pycnogenol®.

Keeping in line with its commitment to science and innovation, comprehensive research and development programs continue to be carried out for the company’s latest ingredient,Robuvit®, for health applications including energy, detox and sports performance. Recently, Horphag Research’s new proprietary ingredient Robuvit®, won Ingredient of the Year for Sport & Energy at the NutraIngredients Awards 2017.

Key Market Areas• Antioxidant • Anti-inflammatory • Circulation • Skin health • Cardiovascular health • Nitric oxide • Energy • Fatigue • Detoxification • Sports performance

Major ProductsPycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. Pycnogenol® has four basic properties — it’s a powerful antioxidant, acts as a natural anti-inflammatory, helps bind to collagen and elastin in the skin and aids in the production of endothelial nitric oxide, which helps to dilate blood vessels.

Robuvit® is a patented extract derived from French oak wood — a venerated tree prized for its resilience and preservative effects. This extract uses natural roburins, unique to oak wood, to increase energy and fend off fatigue, support the liver’s natural detoxification process, and boosts endurance and training efficiency for greater sports performance.

What’s NewPycnogenol® found to normalize cardiovascular risk factors in perimenopausal women. The latest research on Pycnogenol® shows that daily supplementation alleviates symptoms related to perimenopause and reduces cardiovascular risk factors such as high blood pressure. This study indicated that supplementation significantly reduced cardiovascular risk indicator homocysteine by 47% and C-Reactive Protein levels by 60%.

Daily use of Pycnogenol® shown to help curb muscle loss due to aging. A 2016 study published in the Journal of Orthopedics and Traumatology shows that supplementation with Pycnogenol® stabilizes muscles through the aging process to support muscular function and endurance. Study participants demonstrated significant improvement in performing daily tasks such as climbing stairs, carrying items and walking long distances.

Research shows that Robuvit® supports liver function to boost elimination of toxins. A 2016 study reported that daily supplementation with Robuvit® increases liver enzyme capacity required to recover from temporary hepatic damage related to alcohol consumption. Study participants showed significant improvement of typical hangover symptoms such as fatigue, nausea and mild liver enlargement.

Robuvit® found to heighten performance in training and workouts. A 2015 study shows that daily supplementation with Robuvit® during training may help to reduce post- training muscle fatigue, pain and cramping by reducing oxidative stress.

Daily use of Robuvit® shown to alleviate symptoms of fatigue. A 2015 study published in Phytotherapy Research shows that Robuvit® helps to reduce symptoms of fatigue in as little as four weeks. This research builds off of a 2013 study published in Panminerva Medica examining the benefits of Robuvit® for participants with Chronic Fatigue Syndrome (CFS).

Horphag Research USA5 Marine View Plaza, Ste. 403, Hoboken, NJ 07030-5722 Tel.: (201)459-0300 Fax: (201)459-0055 info@pycnogenol.com info@robuvit.com www.pycnogenol.com www.robuvit.com

Key PersonnelFrank Assumma, Director of Sales and Marketing Joel Melillo, Vice President Sales and Marketing Cheryl Costanzo, Director of Global Communications