Madrid, Spain—Branded saffron extract Affron has been awarded a U.S. patent for its positive role in low mood support, according to a press release from Pharmactive Biotech Products. The patent protects the proprietary composition and dosages of affron.

“This new accreditation marks a momentous milestone for affron as it positions it as a leading-edge formulation at the forefront of the US cognitive health category,” said Marguerite Gerritsen, Managing Director for Pharmactive, in the press release.

The ingredient is manufactured using a proprietary extraction procedure, which is specifically designed to optimize the preservation and concentration of the active ingredients with minimal processing and energy use, and without chemicals. A pharmacokinetics study has demonstrated the formulation’s bioavailability and the speed at which it acts upon the body, and it has a proven low-dose threshold.

Affron is supported by six clinical studies demonstrating a positive effect on multiple aspects of mental well-being, including relieving stress, improving mood, inducing positive feelings, and enhancing sleep quality. It has clinically demonstrated capacity to “raise teens’ spirits,” according to the press release.

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“Affron’s mood-enhancement capabilities are owed largely to its role in the inhibition of the reuptake of mood-related neurotransmitters, according to the broader spectrum of scientific literature,” said Alberto Espinel, Head of Strategic R&D in Active and Functional Natural Ingredients for Pharmactive. “Affron possesses a potent antioxidant and anti-inflammatory impact. This capacity not only balances levels of key neurotransmitters, such as serotonin and dopamine, but also fights the oxidative stress that stress produces in the brain.”

The product also now has an “Informed Ingredient” certification mark, recognizing the safety and quality of the product.

“Pharmactive is able to provide nutraceutical and pharma industry players with a truly effective, wholly trustworthy botanical alternative for use in connection with low mood related issues,” concluded Gerritsen. “It also ensures our position as the ideal partner for the US market for natural, botanical mood help.”