"We're very excited about these study findings, which clearly demonstrate KaraLiv's safety and efficacy and how this supplement can have a tangible benefit on overall liver support," said Krishna Rajendran, CEO of Karallief and co-author of the study, in a press release on the topic. "A healthy liver is essential for a good quality of life, because it maintains healthy blood sugar levels and creates critical nutrients the body needs."
The double-blind, parallel, placebo-controlled, randomized clinical trial was published in theInternational Journal of Basic & Clinical Pharmacology.60 participants with mild to moderately elevated liver enzymes were given either a 1,000mg daily dose of KaraLiv or a placebo, and tested over the course of 56 days. By the end of the study, the KaraLiv group achieved:
- 40% reduction in Alanine Aminotransferase (ALT) levels in the blood compared to a 19% reduction in the placebo group. ALT levels are crucial because this helps with protein metabolism. When the liver is impaired, ALT can leak into the bloodstream.
- 53% reduction in Aspartate Aminotransferase (AST) levels in the blood compared to a 24% reduction in the placebo group. AST is an enzyme found in many organs, including the liver. It is released into the blood when damage occurs to any of the organs where it is present.
- 20% reduction in S Alkaline Phosphatase (ALP) levels in the blood compared to a 10% reduction in the placebo group. In the liver, ALP helps in the transport of enzymes and nutrients. ALP levels in the blood increase when there is a blockage or damage to the liver. Subsequent reduction in ALP levels after elevation can indicate that the damage to the liver has reduced or resolved.
- 20% reduction in Serum Bilirubin levels compared to a 12% reduction in the placebo group. Bilirubin is a waste that is generated when red blood cells are broken down, and it cannot be cleared as effectively when the liver is damaged.
- 27% reduction in Malondialdehyde (MDA) levels compared to a 0.6% reduction in the placebo. MDA is a measure of oxidative stress that can occur when the liver malfunctions.
- 20% increase in Superoxide Dismutase (SOD) levels compared to a 0.9% increase in the placebo group. SOD is an enzyme that reduces oxidative stress.
- 21% reduction in Gamma-Glutamyl Transferase (GGT) levels compared to 4.5% reduction in the placebo group. GGT is an enzyme which participates in the metabolism of glutathione, an important antioxidant in the body. GGT is mainly found in the liver, but when the liver is impaired, GGT leaks into the blood.
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KaraLiv is made with standardized herbal ingredients includingMomordica charantia, Phyllanthus niruri, Andrographis paniculata, Brassica rapa, Asparagus racemosus, andZingiber officinale.
