MM is an aggressive form of cancer primarily associated with exposure to asbestos fibers. It has a long latency, non-specific clinical symptoms, and is resistant to chemotherapy. A press release on the topic says that this latest study explored the use of CBP in both drug susceptible and drug-resistant MM cancer cell-types. Researchers found that CBP impaired the viability of cancer cells, self-renewal ability of cancer cells, cell proliferation rate, and cell migration as assessed by wound-healing assay. Onset of apoptosis of cancer cells was determined to occur by activation of intrinsic pathways through an altered ratio of Bax/BC12 proteins.
The authors noted that it might be possible to include CBP administration with drug regimens for MM.